Endocrine Abstracts

Introduction: We do not fully understand why some hypothyroid patients complain of persistent symptoms despite normalisation of TSH with levothyroxine therapy. Recent evidence in adults suggests that polymorphism in deiodinase2 enzyme could lead to lower level of T3 in some tissues and persistence of symptoms. A combination therapy with T3/T4 may improve symptoms especially psychological well-being, mood and memory in such patients. Combination...

Background: In patients with type 1 diabetes (T1D), arterial stiffness is a potential alternative biomarker for cardiovascular (CV) risk as it has recently shown important prognostic value in the development of CVD that is independent from traditional risk factors. Glycemic control by means of HbA1c is a main determinant of arterial stiffness progression, however the relationship with continuous glucose monitoring (CGM)-derived parameters such as time in range (TIR) has not be...

Background: Secondary hypogonadism due to intensive exercise and eating disorders are well documented in females. But there very few reports of secondary hypogonadism due to intensive exercise in male patients.Case presentation: A 34 year old Caucasian male, presented to our clinic with impaired fertility, lack of libido and increased fatigue. On further enquiry, he mentioned that he had starting running 3–4 yrs. ago, and had been running mara...

ObjectiveTo describe two cases of patients presenting with abdominal pain to the gastroenterologists. These were diagnosed with primary hyperparathyroidism and adrenal insufficiency respectively.MethodsTwo case histories, including detailed results of laboratory tests, are presented, and the findings are discussed.ResultsWe present a 62 year old gentleman who was ...

Multiple endocrine neoplasia type 1 (MEN1) is a relatively rare autosomal dominantly inherited condition characterized by hyperplastic and neoplastic disorders of endocrine organs such as the parathyroid, anterior pituitary and gastroenteropancreatic endocrine tissues. Germline mutation of the causative gene, MEN1, which localizes to human chromosome 11q13 and encodes the 610 amino-acid nuclear protein menin, can be identified in most affected subjects. MEN1 gene mutation anal...

The influence of the hypothyroidism (H) on the glucose metabolism (GM) has not been studied by modern methods till now. We described the changes in the effect of insulin on GM in patients in artificial H and after the thyroid hormone therapy (T).Materials and Methods: We have investigated 15 female patients (age 32.8 plus/minus 8.1 years) in H (ssTSH 84.45 plus/minus 19.69 milli international units per litre; fT4 1.68 plus/minus 0.77 picomoles per litre;...

The paediatric diabetes best practice tariff (BPT) was introduced in 2012, with the aim of standardising and improving paediatric diabetes services across England. In the first year, only about 50% of units were claiming the full tariff but this had substantially improved for 2013–2014. It is probably too early to see if there has been a positive impact on outcomes but data from the East Midlands will be presented to look at this in more detail. From 2014, the BPT will al...

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SCS is defined as an adrenal tumor (usually adenoma) with autonomous cortisol secretion and no overt symptoms of Cushing’s syndrome. SCS has attracted much attention because it often is masked by lifestyle-related diseases such as diabetes mellitus (DM), metabolic syndrome (MS) and hypertension. Because of the broad variation in autonomous cortisol secretion among patients, diagnostic criteria for SCS have not been fully established. Furthermore, the cut-off values of the...

Graves’ disease (GD) is a heterogeneous disorder affecting with varying degrees of severity the thyroid and eyes. This variety may suggest that complex interactions between genetic, environmental and endogenous factors influence the clinical course of GD. Although the genetic predisposition to GD is well established, the significance of genotype-phenotype correlations remains controversial. Moreover, the lack of complete phenotypic concordance in twin studies suggested th...